Da Silva Lopes joined the Peterborough United academy in 2013 when he was 14 years old. He previously played at youth level for the Powerleague Colts, this is where he was first spotted by Peterbrough United. Lopes signed a senior contact on 10 March 2015 along with four other graduates He made his senior debut in a 4–3 victory against Crawley Town on 25 April 2015. He then scored his first goal for Peterborough although he was on the losing side of a 3–1 EFL Cup loss against Swansea City in August 2016. He went on to make 86 appearances for Peterborough.

It was announced on 5 June 2018 that Lopes had completed a transfer to Wigan Athletic for an undisclosed fee, thought to be around £1.5 million. On 31 January 2019, he joined EFL League One side Gillingham on loan for the remainder of the 2018–19 season. Despite paying a substantial fee for the service of Leonardo he only played 3 games for Wigan.

On 8 August 2019, Lopes joined Hull City for an undisclosed fee on a three-year deal.